Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

The serine/threonine kinase Akt/PKB is a major downstream effector of growth factor–mediated cell survival. Activated Akt, like Bcl-2 and Bcl-xL, prevents closure of a PT pore component, the voltage-dependent anion channel (VDAC); intracellular acidification; mitochondrial hyperpolarization; and the...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Gottlob, Kathrin, Majewski, Nathan, Kennedy, Scott, Kandel, Eugene, Robey, R. Brooks, Hay, Nissim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2001
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312709/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390360/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.889901
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