Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive pancreatic ductal adenocarcinomas in mice: A mouse model of familial pancreatic cancer

An inactivating germline mutation in BRCA2 is the most common known genetic basis for familial pancreatic cancer (FPC), accounting for 5–10% of inherited cases. A genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) arising on the backdrop of Brca2 deficiency is likely to el...

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Autors principals: Feldmann, Georg, Karikari, Collins, dal Molin, Marco, Duringer, Stephanie, Volkmann, Petra, Bartsch, Detlef K, Bisht, Savita, Koorstra, Jan-Bart, Brossart, Peter, Maitra, Anirban, Fendrich, Volker
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127047/
https://ncbi.nlm.nih.gov/pubmed/21455033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.11.15534
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