A STAT-1 knockout mouse model for Machupo virus pathogenesis

BACKGROUND: Machupo virus (MACV), a member of the Arenaviridae, causes Bolivian hemorrhagic fever, with ~20% lethality in humans. The pathogenesis of MACV infection is poorly understood, and there are no clinically proven treatments for disease. This is due, in part, to a paucity of small animal mod...

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Autori principali: Bradfute, Steven B, Stuthman, Kelly S, Shurtleff, Amy C, Bavari, Sina
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126776/
https://ncbi.nlm.nih.gov/pubmed/21672221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-300
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