Pharmacologic Specificity of Nicotinic Receptor-Mediated Relaxation of Muscarinic Receptor Precontracted Human Gastric Clasp and Sling Muscle Fibers within the Gastroesophageal Junction

Relaxation of gastric clasp and sling muscle fibers is involved the transient lower esophageal sphincter relaxations underlying the pathophysiology of gastroesophageal reflux disease (GERD). These fibers do not contribute tone to the high-pressure zone in GERD patients, indicating their role in path...

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Detalhes bibliográficos
Main Authors: Braverman, Alan S., Vegesna, Anil K., Miller, Larry S., Barbe, Mary F., Tiwana, Mansoor, Hussain, Kashif, Ruggieri, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126643/
https://ncbi.nlm.nih.gov/pubmed/21464333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.177097
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