Identification of a High-Affinity Ligand That Exhibits Complete Aryl Hydrocarbon Receptor Antagonism

The biological functions of the aryl hydrocarbon receptor (AHR) can be delineated into dioxin response element (DRE)-dependent or -independent activities. Ligands exhibiting either full or partial agonist activity, e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin and α-naphthoflavone, have been demonstrate...

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Detalhes bibliográficos
Main Authors: Smith, Kayla J., Murray, Iain A., Tanos, Rachel, Tellew, John, Boitano, Anthony E., Bisson, William H., Kolluri, Siva K., Cooke, Michael P., Perdew, Gary H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Cellular and Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126639/
https://ncbi.nlm.nih.gov/pubmed/21493753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.178392
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