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HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

The Nef protein is an important HIV virulence factor that promotes the degradation of host proteins to augment virus production and facilitate immune evasion. The best-characterized targets of Nef are major histocompatibility complex class I (MHC-I) and CD4, but Nef also has been reported to target...

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Autori principali: Leonard, Jolie A., Filzen, Tracy, Carter, Christoph C., Schaefer, Malinda, Collins, Kathleen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126561/
https://ncbi.nlm.nih.gov/pubmed/21543478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00229-11
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