An Exploratory Trial of Cyclooxygenase Type 2 Inhibitor in HIV-1 Infection: Downregulated Immune Activation and Improved T Cell-Dependent Vaccine Responses

Chronic HIV infection is characterized by chronic immune activation and dysfunctional T cells with elevated intracellular cyclic AMP (cAMP), which inhibits the T cell activation capability. cAMP may be induced by prostaglandin E(2) following lipopolysaccharide (LPS)-induced upregulation of cyclooxyg...

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Main Authors: Pettersen, Frank O., Torheim, Eirik A., Dahm, Anders E. A., Aaberge, Ingeborg S., Lind, Andreas, Holm, Malin, Aandahl, Einar M., Sandset, Per M., Taskén, Kjetil, Kvale, Dag
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126508/
https://ncbi.nlm.nih.gov/pubmed/21490090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00073-11
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