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Unmasking the Active Helicase Conformation of Nonstructural Protein 3 from Hepatitis C Virus
The nonstructural protein 3 (NS3) helicase/protease is an important component of the hepatitis C virus (HCV) replication complex. We hypothesized that a specific β-strand tethers the C terminus of the helicase domain to the protease domain, thereby maintaining HCV NS3 in a compact conformation that...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Microbiology
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3126282/ https://ncbi.nlm.nih.gov/pubmed/21325413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02130-10 |
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