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Determinants of the Hepatitis C Virus Nonstructural Protein 2 Protease Domain Required for Production of Infectious Virus

The hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a dimeric multifunctional hydrophobic protein with an essential but poorly understood role in infectious virus production. We investigated the determinants of NS2 function in the HCV life cycle. On the basis of the crystal structure of the...

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Detalles Bibliográficos
Main Authors: Dentzer, Thomas G., Lorenz, Ivo C., Evans, Matthew J., Rice, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786863/
https://ncbi.nlm.nih.gov/pubmed/19812162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01184-09
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