The Role of LAT in Increased CD8(+) T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

Herpes simplex virus (HSV) infection is a classic example of latent viral infection in humans and experimental animal models. The HSV-1 latency-associated transcript (LAT) plays a major role in the HSV-1 latency reactivation cycle and thus in recurrent disease. Whether the presence of LAT leads to g...

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Hauptverfasser: Allen, Sariah J., Hamrah, Pedram, Gate, David, Mott, Kevin R., Mantopoulos, Dimosthenis, Zheng, Lixin, Town, Terrence, Jones, Clinton, von Andrian, Ulrich H., Freeman, Gordon J., Sharpe, Arlene H., BenMohamed, Lbachir, Ahmed, Rafi, Wechsler, Steven L., Ghiasi, Homayon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126262/
https://ncbi.nlm.nih.gov/pubmed/21307196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02290-10
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