Mutagenesis of Varicella-Zoster Virus Glycoprotein I (gI) Identifies a Cysteine Residue Critical for gE/gI Heterodimer Formation, gI Structure, and Virulence in Skin Cells

Varicella-zoster virus (VZV) is the alphaherpesvirus that causes chicken pox (varicella) and shingles (zoster). The two VZV glycoproteins gE and gI form a heterodimer that mediates efficient cell-to-cell spread. Deletion of gI yields a small-plaque-phenotype virus, ΔgI virus, which is avirulent in h...

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Bibliographic Details
Main Authors: Oliver, Stefan L., Sommer, Marvin H., Reichelt, Mike, Rajamani, Jaya, Vlaycheva-Beisheim, Leonssia, Stamatis, Shaye, Cheng, Jason, Jones, Carol, Zehnder, James, Arvin, Ann M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126246/
https://ncbi.nlm.nih.gov/pubmed/21345964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02596-10
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