Deletion of Major Nonessential Genomic Regions in the Vaccinia Virus Lister Strain Enhances Attenuation without Altering Vaccine Efficacy in Mice

The vaccinia virus (VACV) Lister strain was one of the vaccine strains that enabled smallpox eradication. Although the strain is most often harmless, there have been numerous incidents of mild to life-threatening accidents with this strain and others. In an attempt to further attenuate the Lister st...

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Detalhes bibliográficos
Main Authors: Dimier, Julie, Ferrier-Rembert, Audrey, Pradeau-Aubreton, Karine, Hebben, Matthias, Spehner, Danièle, Favier, Anne-Laure, Gratier, Danielle, Garin, Daniel, Crance, Jean-Marc, Drillien, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126188/
https://ncbi.nlm.nih.gov/pubmed/21367889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02359-10
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