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Exploring the Fitness Landscape of an RNA Virus by Using a Universal Barcode Microarray

Studies of viral pathogenesis have relied heavily on analyses of specific clones and their genetic determinants of virulence. It is sometimes difficult to apply this reductionist approach to the study of RNA viruses, which by virtue of their very high mutation rates, exist as a complex mixture of mu...

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Hlavní autoři: Lauring, Adam S., Andino, Raul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126141/
https://ncbi.nlm.nih.gov/pubmed/21289109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02217-10
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