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RNA interference is mediated by 21- and 22-nucleotide RNAs

Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 21- and 22-nt RNA fragments are the sequence-specific mediators of RNAi. The short interfe...

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Udgivet i:Genes Dev
Principais autores: Elbashir, Sayda M., Lendeckel, Winfried, Tuschl, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312613/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157775/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.862301
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