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The Hippo Signaling Pathway in Development and Cancer
First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124840/ https://ncbi.nlm.nih.gov/pubmed/20951342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.09.011 |
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