The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

BACKGROUND: We have recently discovered that the two tryptophans of human β2-microglobulin have distinctive roles within the structure and function of the protein. Deeply buried in the core, Trp95 is essential for folding stability, whereas Trp60, which is solvent-exposed, plays a crucial role in pr...

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Hlavní autoři: Raimondi, Sara, Barbarini, Nicola, Mangione, Palma, Esposito, Gennaro, Ricagno, Stefano, Bolognesi, Martino, Zorzoli, Irene, Marchese, Loredana, Soria, Cristina, Bellazzi, Riccardo, Monti, Maria, Stoppini, Monica, Stefanelli, Mario, Magni, Paolo, Bellotti, Vittorio
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124429/
https://ncbi.nlm.nih.gov/pubmed/21663612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-11-159
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