A Small Molecule MIF Antagonist Protects against Glomerulonephritis in Lupus-prone NZB/NZW F1 and MRL/lpr Mice

Autoimmunity leads to the activation of innate effector pathways, pro-inflammatory cytokine production, and end-organ injury. Macrophage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates the recruitment and retention of monocytes via CD74 and associated...

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Autori principali: Leng, Lin, Chen, Liang, Fan, Juan, Greven, Dorothee, Arjona, Alvaro, Du, Xin, Austin, David, Kashgarian, Michael, Yin, Zhinan, Huang, Xiao R., Lan, Hui Y., Lolis, Elias, Nikolic-Paterson, David, Bucala, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124407/
https://ncbi.nlm.nih.gov/pubmed/21106847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001767
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