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A Small Molecule MIF Antagonist Protects against Glomerulonephritis in Lupus-prone NZB/NZW F1 and MRL/lpr Mice
Autoimmunity leads to the activation of innate effector pathways, pro-inflammatory cytokine production, and end-organ injury. Macrophage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates the recruitment and retention of monocytes via CD74 and associated...
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| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124407/ https://ncbi.nlm.nih.gov/pubmed/21106847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001767 |
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