Inhibiting TGF-β Activity Improves Respiratory Function in mdx Mice

Respiratory function is the main cause of mortality in patients with Duchenne muscular dystrophy (DMD). Elevated levels of TGF-β play a key role in the pathophysiology of DMD. To determine whether therapeutic attenuation of TGF-β signaling improves respiratory function, mdx mice were treated from 2...

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Autors principals: Nelson, Carol A., Hunter, R. Bridge, Quigley, Lindsay A., Girgenrath, Stefan, Weber, William D., McCullough, Jennifer A., Dinardo, Carol J., Keefe, Kelly A., Ceci, Lorena, Clayton, Nicholas P., McVie-Wylie, Alison, Cheng, Seng H., Leonard, John P., Wentworth, Bruce M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2011
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124227/
https://ncbi.nlm.nih.gov/pubmed/21641384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.02.024
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