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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
There is now considerable and increasing evidence for a causal role of aberrant activity of the Ras superfamily of small GTPases in human cancers. These GTPases act as GDP-GTP-regulated binary switches that control many fundamental cellular processes. A common mechanism of GTPase deregulation in can...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124093/ https://ncbi.nlm.nih.gov/pubmed/21102635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2960 |
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