Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction

Budding of HIV-1 requires the binding of the PTAP late domain of the Gag p6 protein to the UEV domain of the TSG101 subunit of ESCRT-I. The normal function of this motif in cells is in receptor downregulation. Here we report the 1.4 to 1.6 Å structures of the human TSG101 UEV domain alone and with w...

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Autori principali: Im, Young Jun, Kuo, Lillian, Ren, Xuefeng, Burgos, Patricia V., Zhao, Xue Zhi, Liu, Fa, Burke, Terrence R., Bonifacino, Juan S., Freed, Eric O., Hurley, James H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124085/
https://ncbi.nlm.nih.gov/pubmed/21070952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.08.010
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