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Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction
Budding of HIV-1 requires the binding of the PTAP late domain of the Gag p6 protein to the UEV domain of the TSG101 subunit of ESCRT-I. The normal function of this motif in cells is in receptor downregulation. Here we report the 1.4 to 1.6 Å structures of the human TSG101 UEV domain alone and with w...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124085/ https://ncbi.nlm.nih.gov/pubmed/21070952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.08.010 |
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