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The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens

We previously found that lenses lacking the Acvr1 gene, which encodes a bone morphogenetic protein (BMP) receptor, had abnormal proliferation and cell death in epithelial and cortical fiber cells. We tested whether the tumor suppressor protein p53 (encoded by Trp53) affected this phenotype. Acvr1 co...

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書誌詳細
主要な著者: Wiley, Luke A., Rajagopal, Ramya, Dattilo, Lisa K., Beebe, David C.
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists Limited 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124053/
https://ncbi.nlm.nih.gov/pubmed/21504908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.006593
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