The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

The transcription factor REST silences neuronal gene expression in non-neuronal cells. In neurons, the protein is sequestered in the cytoplasm in part through binding to huntingtin. Polyglutamine expansions in huntingtin, which causes Huntington's disease (HD), abrogates REST-huntingtin binding...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Packer, Amy N., Xing, Yi, Harper, Scott Q., Jones, Lesley, Davidson, Beverly L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2008
Pynciau:
Brief Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124002/
https://ncbi.nlm.nih.gov/pubmed/19118166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2390-08.2008
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