β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

Amyloid deposition and reduced β-cell mass are pathological hallmarks of the pancreatic islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with decreased β-cell mass is debated. We investigated the possible relationship and, for the first time, determined wheth...

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Hlavní autoři: Jurgens, Catherine A., Toukatly, Mirna N., Fligner, Corinne L., Udayasankar, Jayalakshmi, Subramanian, Shoba L., Zraika, Sakeneh, Aston-Mourney, Kathryn, Carr, Darcy B., Westermark, Per, Westermark, Gunilla T., Kahn, Steven E., Hull, Rebecca L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123989/
https://ncbi.nlm.nih.gov/pubmed/21641386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.02.036
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