Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues

BACKGROUND: CD4-binding site (CD4bs) alterations in gp120 contribute to HIV-1 envelope (Env) mediated fusogenicity and the ability of gp120 to utilize low levels of cell-surface CD4. In a recent study, we constructed three-dimensional models of gp120 to illustrate CD4bs conformations associated with...

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Main Authors: Gray, Lachlan, Sterjovski, Jasminka, Ramsland, Paul A, Churchill, Melissa J, Gorry, Paul R
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Short Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123634/
https://ncbi.nlm.nih.gov/pubmed/21635737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-42
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