A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3

Deregulated IL-12 and IL-23 production from activated myeloid lineage cells is a key driver of numerous T cell-dependent autoimmune and inflammatory diseases. IL-12 and IL-23 share a common p40 subunit encoded by Il12b, which is negatively regulated at the transcriptional level by the STAT3 (signal...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Smith, Amber M., Qualls, Joseph E., O'Brien, Kevin, Balouzian, Liza, Johnson, Peter F., Schultz-Cherry, Stacey, Smale, Stephen T., Murray, Peter J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123121/
https://ncbi.nlm.nih.gov/pubmed/21566115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249235
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