CDK6 kinase activity is required for thymocyte development

Cyclin-dependent kinase-6 (CDK6) is required for early thymocyte development and tumorigenesis. To mechanistically dissect the role of CDK6 in thymocyte development, we generated and analyzed mutant knock-in mice and found that mice expressing a kinase-dead Cdk6 allele (Cdk6(K43M)) had a pronounced...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Hu, Miaofen G., Deshpande, Amit, Schlichting, Nicolette, Hinds, Elisabeth A., Mao, Changchuin, Dose, Marei, Hu, Guo-fu, Van Etten, Richard A., Gounari, Fotini, Hinds, Philip W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122937/
https://ncbi.nlm.nih.gov/pubmed/21508411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-300517
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker