Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish

Abstract Niemann-Pick disease, type C (NP-C), often associated with Niemann-Pick disease, type C1 (NPC1) mu­tations, is a cholesterol-storage disorder characterized by cellular lipid accumulation, neurodegeneration, and reduced steroid production. To study NPC1 function in vivo, we cloned zebrafish...

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Main Authors: Schwend, Tyler, Loucks, Evyn J., Snyder, Diana, Ahlgren, Sara C.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122913/
https://ncbi.nlm.nih.gov/pubmed/21576600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M012377
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