Identification and Functional Relevance of de novo DNA Methylation in Cancerous B-Cell Populations

Epigenetic remodeling is a hallmark of cancer, with the frequent acquisition of de novo DNA methylation in CpG islands. However, the functional relevance of de novo DNA methylation in cancer is less well-defined. To begin to address this issue in B-cells, we used BeadArray assays to survey the methy...

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Detalhes bibliográficos
Main Authors: Wang, Xiao-Ming, Greiner, Timothy C., Bibikova, Marina, Pike, Brian L., Siegmund, Kimberly D., Sinha, Uttam K., Müschen, Markus, Jaeger, Erich B., Weisenburger, Dennis J., Chan, Wing C., Shibata, Darryl, Fan, Jian-Bing, Hacia, Joseph G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122883/
https://ncbi.nlm.nih.gov/pubmed/20069569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22461
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