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(18)FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer
PURPOSE: To evaluate 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography imaging ((18)FDG-PET) as a predictive, non-invasive, pharmacodynamic (PD) biomarker of response following administration of a small-molecule IGF-1R/IR inhibitor, OSI-906. EXPERIMENTAL DESIGN: In vitro uptake studies...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3122480/ https://ncbi.nlm.nih.gov/pubmed/21257723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2274 |
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