Use of the NP-40 Detergent-Mediated Assay in Discovery of Inhibitors of β-Hematin Crystallization

The protozoan parasite responsible for malaria affects over 500 million people each year. Current antimalarials have experienced decreased efficacy due to the development of drug-resistant strains of Plasmodium spp., resulting in a critical need for the discovery of new antimalarials. Hemozoin, a cr...

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Main Authors: Sandlin, Rebecca D., Carter, Melissa D., Lee, Patricia J., Auschwitz, Jennifer M., Leed, Susan E., Johnson, Jacob D., Wright, David W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122397/
https://ncbi.nlm.nih.gov/pubmed/21518844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00121-11
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