Dose Range Evaluation of Mycograb C28Y Variant, a Human Recombinant Antibody Fragment to Heat Shock Protein 90, in Combination with Amphotericin B-Desoxycholate for Treatment of Murine Systemic Candidiasis

Systemic candidiasis causes significant mortality in patients despite amphotericin B (AMB) therapy. Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, is closely related to Mycograb, which showed a survival advantage in combination with AMB in a phase III human tr...

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Autors principals: Louie, Arnold, Stein, Daniel S., Zack, Julia Z., Liu, Weiguo, Conde, Haley, Fregeau, Christine, VanScoy, Brian D., Drusano, George L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122395/
https://ncbi.nlm.nih.gov/pubmed/21502626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01324-10
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