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Adamantyl Glycosphingolipids Provide a New Approach to the Selective Regulation of Cellular Glycosphingolipid Metabolism

Mammalian glycosphingolipid (GSL) precursor monohexosylceramides are either glucosyl- or galactosylceramide (GlcCer or GalCer). Most GSLs derive from GlcCer. Substitution of the GSL fatty acid with adamantane generates amphipathic mimics of increased water solubility, retaining receptor function. We...

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Detalhes bibliográficos
Main Authors: Kamani, Mustafa, Mylvaganam, Murugesapillai, Tian, Robert, Rigat, Brigitte, Binnington, Beth, Lingwood, Clifford
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122201/
https://ncbi.nlm.nih.gov/pubmed/21518770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.207670
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