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Studies on Lactoferricin-derived Escherichia coli Membrane-active Peptides Reveal Differences in the Mechanism of N-Acylated Versus Nonacylated Peptides

To improve the low antimicrobial activity of LF11, an 11-mer peptide derived from human lactoferricin, mutant sequences were designed based on the defined structure of LF11 in the lipidic environment. Thus, deletion of noncharged polar residues and strengthening of the hydrophobic N-terminal part up...

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Библиографические подробности
Главные авторы: Zweytick, Dagmar, Deutsch, Günter, Andrä, Jörg, Blondelle, Sylvie E., Vollmer, Ekkehard, Jerala, Roman, Lohner, Karl
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122186/
https://ncbi.nlm.nih.gov/pubmed/21515687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195412
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