Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

Antibacterial peptide acylation, which mimics the structure of the natural lipopeptide polymyxin B, increases antimicrobial and endotoxin-neutralizing activities. The interaction of the lactoferricin-derived peptide LF11 and its N-terminally acylated analogue, lauryl-LF11, with different chemotypes...

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Autores principales: Andrä, Jörg, Lohner, Karl, Blondelle, Sylvie E., Jerala, Roman, Moriyon, Ignacio, Koch, Michel H. J., Garidel, Patrick, Brandenburg, Klaus
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2004
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134681/
https://ncbi.nlm.nih.gov/pubmed/15344905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041270
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