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Use of fully modified 2′-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos

Antisense oligonucleotides are commonly employed to study the roles of genes in development. Although morpholino phosphorodiamidate oligonucleotides (morpholinos) are widely used to block translation or splicing of target gene products, the usefulness of other modifications in mediating RNase-H inde...

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Hlavní autoři: Schneider, Patricia N., Olthoff, John T., Matthews, Abby J., Houston, Douglas W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121920/
https://ncbi.nlm.nih.gov/pubmed/21442720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.20689
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