Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase

Heparin has been shown to regulate human neutrophil elastase (HNE) activity. We have assessed the regulatory effect of heparin on Tissue Inhibitor of Metalloproteases-1 [TIMP-1] hydrolysis by HNE employing the recombinant form of TIMP-1 and correlated FRET-peptides comprising the TIMP-1 cleavage sit...

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Detalhes bibliográficos
Main Authors: Nunes, Gabriel L. C., Simões, Alyne, Dyszy, Fábio H., Shida, Claudio S., Juliano, Maria A., Juliano, Luiz, Gesteira, Tarsis F., Nader, Helena B., Murphy, Gillian, Chaffotte, Alain F., Goldberg, Michel E., Tersariol, Ivarne L. S., Almeida, Paulo C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121799/
https://ncbi.nlm.nih.gov/pubmed/21731773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021525
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