Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells

BACKGROUND: The sensitivity of non-small cell lung cancer (NSCLC) patients to EGFR tyrosine kinase inhibitors (TKIs) is strongly associated with activating EGFR mutations. Although not as sensitive as patients harboring these mutations, some patients with wild-type EGFR (wtEGFR) remain responsive to...

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Autori principali: Chen, Yun-Ju, Huang, Wei-Chien, Wei, Ya-Ling, Hsu, Sheng-Chieh, Yuan, Ping, Lin, Heather Y., Wistuba, Ignacio I., Lee, J. Jack, Yen, Chia-Jui, Su, Wu-Chou, Chang, Kwang-Yu, Chang, Wen-Chang, Chou, Tse-Chuan, Chou, Chao-Kai, Tsai, Chang-Hai, Hung, Mien-Chie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121773/
https://ncbi.nlm.nih.gov/pubmed/21731744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021428
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