Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells

BACKGROUND: The sensitivity of non-small cell lung cancer (NSCLC) patients to EGFR tyrosine kinase inhibitors (TKIs) is strongly associated with activating EGFR mutations. Although not as sensitive as patients harboring these mutations, some patients with wild-type EGFR (wtEGFR) remain responsive to...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Chen, Yun-Ju, Huang, Wei-Chien, Wei, Ya-Ling, Hsu, Sheng-Chieh, Yuan, Ping, Lin, Heather Y., Wistuba, Ignacio I., Lee, J. Jack, Yen, Chia-Jui, Su, Wu-Chou, Chang, Kwang-Yu, Chang, Wen-Chang, Chou, Tse-Chuan, Chou, Chao-Kai, Tsai, Chang-Hai, Hung, Mien-Chie
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121773/
https://ncbi.nlm.nih.gov/pubmed/21731744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021428
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky