The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a sing...

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Autores principales: Kisby, Glen E., Fry, Rebecca C., Lasarev, Michael R., Bammler, Theodor K., Beyer, Richard P., Churchwell, Mona, Doerge, Daniel R., Meira, Lisiane B., Palmer, Valerie S., Ramos-Crawford, Ana-Luiza, Ren, Xuefeng, Sullivan, Robert C., Kavanagh, Terrance J., Samson, Leona D., Zarbl, Helmut, Spencer, Peter S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121718/
https://ncbi.nlm.nih.gov/pubmed/21731631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020911
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