The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a sing...

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Detalhes bibliográficos
Main Authors: Kisby, Glen E., Fry, Rebecca C., Lasarev, Michael R., Bammler, Theodor K., Beyer, Richard P., Churchwell, Mona, Doerge, Daniel R., Meira, Lisiane B., Palmer, Valerie S., Ramos-Crawford, Ana-Luiza, Ren, Xuefeng, Sullivan, Robert C., Kavanagh, Terrance J., Samson, Leona D., Zarbl, Helmut, Spencer, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121718/
https://ncbi.nlm.nih.gov/pubmed/21731631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020911
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