The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a sing...

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Autori principali: Kisby, Glen E., Fry, Rebecca C., Lasarev, Michael R., Bammler, Theodor K., Beyer, Richard P., Churchwell, Mona, Doerge, Daniel R., Meira, Lisiane B., Palmer, Valerie S., Ramos-Crawford, Ana-Luiza, Ren, Xuefeng, Sullivan, Robert C., Kavanagh, Terrance J., Samson, Leona D., Zarbl, Helmut, Spencer, Peter S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121718/
https://ncbi.nlm.nih.gov/pubmed/21731631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020911
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