Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

BACKGROUND: Axl, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion,...

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Autores principales: Weinger, Jason G, Brosnan, Celia F, Loudig, Olivier, Goldberg, Michael F, Macian, Fernando, Arnett, Heather A, Prieto, Anne L, Tsiperson, Vladislav, Shafit-Zagardo, Bridget
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121615/
https://ncbi.nlm.nih.gov/pubmed/21569627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-49
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