Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB

The IκB kinase (IKK) complex regulates activation of NF-κB, a critical transcription factor in mediating inflammatory and immune responses. Not surprisingly, therefore, many viruses seek to inhibit NF-κB activation. The vaccinia virus B14 protein contributes to virus virulence by binding to the IKKβ...

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Autori principali: Benfield, Camilla T. O., Mansur, Daniel S., McCoy, Laura E., Ferguson, Brian J., Bahar, Mohammad W., Oldring, Asa P., Grimes, Jonathan M., Stuart, David I., Graham, Stephen C., Smith, Geoffrey L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121528/
https://ncbi.nlm.nih.gov/pubmed/21474453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.231381
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