Gephyrin Regulates GABAergic and Glutamatergic Synaptic Transmission in Hippocampal Cell Cultures

Gephyrin is a scaffold protein essential for stabilizing glycine and GABA(A) receptors at inhibitory synapses. Here, recombinant intrabodies against gephyrin (scFv-gephyrin) were used to assess whether this protein exerts a transynaptic action on GABA and glutamate release. Pair recordings from inte...

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Détails bibliographiques
Auteurs principaux: Varley, Zeynep Kasap, Pizzarelli, Rocco, Antonelli, Roberta, Stancheva, Stefka H., Kneussel, Matthias, Cherubini, Enrico, Zacchi, Paola
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Neurobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121485/
https://ncbi.nlm.nih.gov/pubmed/21507951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234641
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