Mapping the Intermedilysin-Human CD59 Receptor Interface Reveals a Deep Correspondence with the Binding Site on CD59 for Complement Binding Proteins C8α and C9

CD59 is a glycosylphosphatidylinositol-anchored protein that inhibits the assembly of the terminal complement membrane attack complex (MAC) pore, whereas Streptococcus intermedius intermedilysin (ILY), a pore forming cholesterol-dependent cytolysin (CDC), specifically binds to human CD59 (hCD59) to...

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Detalhes bibliográficos
Main Authors: Wickham, Stephanie E., Hotze, Eileen M., Farrand, Allison J., Polekhina, Galina, Nero, Tracy L., Tomlinson, Stephen, Parker, Michael W., Tweten, Rodney K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121471/
https://ncbi.nlm.nih.gov/pubmed/21507937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237446
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