Inhibition of Alanine Aminotransferase in Silico and in Vivo Promotes Mitochondrial Metabolism to Impair Malignant Growth

Cancer cells commonly exhibit increased nonoxidative d-glucose metabolism whereas induction of mitochondrial metabolism may impair malignant growth. We have first used an in silico method called elementary mode analysis to identify inhibition of ALAT (l-alanine aminotransferase) as a putative target...

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Detalhes bibliográficos
Main Authors: Beuster, Gregor, Zarse, Kim, Kaleta, Christoph, Thierbach, René, Kiehntopf, Michael, Steinberg, Pablo, Schuster, Stefan, Ristow, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121379/
https://ncbi.nlm.nih.gov/pubmed/21540181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205229
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