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Prevention of benzyl alcohol-induced aggregation of chymotrypsinogen by PEGylation
Addition of the antimicrobial preservative benzyl alcohol to reconstitution buffer promotes the formation of undesirable aggregates in multidose protein formulations. Herein we investigated the efficiency of PEGylation to prevent benzyl alcohol-induced aggregation of the model protein α-chymotrypsin...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3121166/ https://ncbi.nlm.nih.gov/pubmed/21585378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.2042-7158.2011.01288.x |
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