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Multiple Insulin Degrading Enzyme Variants Alter In Vitro Reporter Gene Expression
The insulin degrading enzyme (IDE) variant, v311 (rs6583817), is associated with increased post-mortem cerebellar IDE mRNA, decreased plasma β-amyloid (Aβ), decreased risk for Alzheimer's disease (AD) and increased reporter gene expression, suggesting that it is a functional variant driving inc...
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| Päätekijät: | , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3120874/ https://ncbi.nlm.nih.gov/pubmed/21731745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021429 |
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