P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

BACKGROUND: Metastatic melanoma represents a major clinical problem. Its incidence continues to rise in western countries and there are currently no curative treatments. While mutation of the P53 tumour suppressor gene is a common feature of many types of cancer, mutational inactivation of P53 in me...

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Detalhes bibliográficos
Main Authors: Avery-Kiejda, Kelly A, Bowden, Nikola A, Croft, Amanda J, Scurr, Lyndee L, Kairupan, Carla F, Ashton, Katie A, Talseth-Palmer, Bente A, Rizos, Helen, Zhang, Xu D, Scott, Rodney J, Hersey, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120805/
https://ncbi.nlm.nih.gov/pubmed/21615965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-203
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