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Rapid and accurate ranking of binding affinities of epidermal growth factor receptor sequences with selected lung cancer drugs

The epidermal growth factor receptor (EGFR) is a major target for drugs in treating lung carcinoma. Mutations in the tyrosine kinase domain of EGFR commonly arise in human cancers, which can cause drug sensitivity or resistance by influencing the relative strengths of drug and ATP-binding. In this s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wan, Shunzhou, Coveney, Peter V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119879/
https://ncbi.nlm.nih.gov/pubmed/21227963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2010.0609
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