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Sphingosine-1-phosphate Acting via the S1P(1) Receptor is a Downstream Signaling Pathway in Ceramide-Induced Hyperalgesia
Ceramide is a potent pro-inflammatory sphingolipid recently shown to exert potent hyperalgesic responses in rats. Once generated, ceramide is converted by sphingosine kinase (SphK) 1 and/or 2 to one of its active metabolite sphingosine-1-phosphate (S1P), which, in turn, signals through G-protein cou...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3119782/ https://ncbi.nlm.nih.gov/pubmed/21605625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2011.05.018 |
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